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Scientist 1

Title: Scientist 1, Molecular Biology, Cell Culture Process Development
Employee Type: FTE
Location: United States - Novato, California
SUMMARY:
The Cell Culture Process Development department at BioMarin Pharmaceutical Inc. is seeking an experienced molecular biologist at the Scientist 1 level for research and development activities. This individual will be part of a group focusing on optimizing production of recombinant viral vectors for BioMarin's gene therapy program.
The successful candidate will work both independently and as part of a team on design and optimization of viral vectors and host cell lines with the goal of improving the production and performance of viral vectors.
RESPONSIBILITIES:
Viral vector design and small-scale production
Characterization assays to evaluate performance of viral vectors
Host cell line engineering, testing, and characterization
Being self-motivated, proactive, and able to design, plan, and perform experiments independently
Strong ability to think critically; demonstrated troubleshooting and problem solving skills
Flexibility in a fast-paced, changing environment; be willing to accept responsibilities outside of the initial job description
Closely interact with other team members; development of internal and external collaborations
EDUCATION
Ph.D. in cellular or molecular biology or in a related field. Two or more years of postdoctoral experience in academia or in the biotechnological industry is strongly preferred.
EXPERIENCE
Required:
Hands-on expertise in molecular biology methods
Proficiency with DNA analysis software, cloning and primer design
Analytical tools: RT-qPCR, ELISA, western blot, electrophoresis
Critical thinking, excellent data analysis and interpretation skills
Good interpersonal, verbal and written communication skills. Proficiency in Microsoft Word, Excel, and PowerPoint.
Presentation of results in written and oral formats
Desired:
Background in virology (AAV, lentivirus, HIV)
Viral vector design, small-scale production and virus transduction
Next generation DNA and RNA sequencing methods and library preparation
Mammalian and insect cell culture
Design of vectors for recombinant protein expression
Cell transfection and clone selection

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